Verapamil and Its Role in Diabetes

Autoimmune pancreatic β-cell loss and destruction play a key role in the pathogenesis and development of type 1 diabetes, with a prospective increased risk for developing micro- and macrovascular complications. In this regard, orally administrated verapamil, a calcium channel antagonist, usually int...

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Bibliographic Details
Published in:Diabetology 2022-09, Vol.3 (3), p.393-406
Main Authors: Zimmermann, Paul, Aberer, Felix, Eckstein, Max L., Haupt, Sandra, Erlmann, Maximilian P., Moser, Othmar
Format: Article
Language:English
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Summary:Autoimmune pancreatic β-cell loss and destruction play a key role in the pathogenesis and development of type 1 diabetes, with a prospective increased risk for developing micro- and macrovascular complications. In this regard, orally administrated verapamil, a calcium channel antagonist, usually intended for use as an anti-arrhythmic drug, has previously shown potential beneficial effects on β-cell preservation in new-onset type 1 diabetes. Furthermore, observational data suggest a reduced risk of type 2 diabetes development. The underlying pathophysiological mechanisms are not well investigated and remain widely inconclusive. The aim of this narrative review was to detail the role of verapamil in promoting endogenous β-cell function, potentially eligible for early treatment in type 1 diabetes, and to summarize existing evidence on its effect on glycemia in individuals with type 2 diabetes.
ISSN:2673-4540
2673-4540
DOI:10.3390/diabetology3030030