Mechanisms of Immune Evasion in PTEN Loss Prostate Cancer

PTEN (phosphatase and tensin homolog) is a frequently lost tumor suppressor gene in prostate cancer, leading to aggressive tumor behavior and poor clinical outcomes. PTEN loss results in aberrant activation of the PI3K/AKT/mTOR pathway, promoting oncogenesis. These alterations also lead to an immuno...

Full description

Saved in:
Bibliographic Details
Published in:Immuno 2024-11, Vol.4 (4), p.444-460
Main Authors: Esteban-Villarrubia, Jorge, Ballesteros, Pablo Alvarez, Martín-Serrano, Miguel, Vico, María Ruiz, Funes, Juan M, de Velasco, Guillermo, Castro, Elena, Olmos, David, Castellano, Daniel, González-Billalabeitia, Enrique
Format: Article
Language:English
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:PTEN (phosphatase and tensin homolog) is a frequently lost tumor suppressor gene in prostate cancer, leading to aggressive tumor behavior and poor clinical outcomes. PTEN loss results in aberrant activation of the PI3K/AKT/mTOR pathway, promoting oncogenesis. These alterations also lead to an immunosuppressive tumor microenvironment with altered immune cell infiltration, cytokine profiles, and immune checkpoint regulation. This review aims to provide a comprehensive overview of the mechanisms underlying PTEN loss in prostate cancer and the consequent immune alterations observed in this subtype, thus underscoring the importance of understanding PTEN-mediated immune modulation for the development of effective therapeutic interventions in prostate cancer.
ISSN:2673-5601
2673-5601
DOI:10.3390/immuno4040028