Metabolic Syndrome Spectrum in Children with Classic Congenital Adrenal Hyperplasia—A Comprehensive Review

Children with a classic form of congenital adrenal hyperplasia (CCAH) have a potentially increased risk of unfavorable cardiometabolic events due to the interplay of corticosteroid treatment, hyperandrogenism, and other factors. Although readily recognized in adults, these aspects are frequently ove...

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Bibliographic Details
Published in:Metabolites 2025-02, Vol.15 (2), p.89
Main Authors: Panic Zaric, Sanja, Milenkovic, Tatjana, Todorovic, Sladjana, Mitrovic, Katarina, Cvetkovic, Dimitrije, Cehic, Maja, Vekic, Jelena, Dumic, Katja, Vukovic, Rade
Format: Article
Language:English
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Summary:Children with a classic form of congenital adrenal hyperplasia (CCAH) have a potentially increased risk of unfavorable cardiometabolic events due to the interplay of corticosteroid treatment, hyperandrogenism, and other factors. Although readily recognized in adults, these aspects are frequently overlooked in children and youth with CCAH; Aim: To review the evidence available from studies regarding cardiometabolic health outcomes in CCAH patients; Methods: A review of the literature was performed following PRISMA guidelines, including studies published between 2000 and 2024. We included studies reporting cardiometabolic outcomes in children and adolescents (
ISSN:2218-1989
2218-1989
DOI:10.3390/metabo15020089