Hospital-Based Surveillance of Respiratory Viruses Among Children Under Five Years of Age with ARI and SARI in Eastern UP, India

• Published in: Viruses 2024-12, Vol.17 (1), p.27
• Main Authors: Deval, Hirawati, Srivastava, Mitali, Srivastava, Neha, Kumar, Niraj, Agarwal, Aman, Potdar, Varsha, Mehta, Anita, Sharma, Bhoopendra, Beniwal, Rohit, Singh, Rajeev, Singh, Amresh Kumar, Gaur, Vivek, Mittal, Mahima, Dwivedi, Gaurav Raj, Behera, Sthita Pragnya, Kavathekar, Asif, Prajapati, Sanjay, Yadav, Sachin, Gautam, Dipti, Kumar, Nalin, Iqbal, Asif, Kant, Rajni, Murhekar, Manoj
• Format: Article
• Language: English
• Subjects: Adenoviruses; Age; ARI; Child, Preschool; Children; Coinfection - epidemiology; Coinfection - virology; Female; Fever; Hospitals; human metapneumovirus (hMPV); Humans; India - epidemiology; Infant; Infections; Influenza; Male; Molecular biology; Parainfluenza; parainfluenza virus (PIV); Pathogens; Patients; Pediatrics; Pneumonia; Prevalence; Public health; Regression analysis; Respiratory diseases; Respiratory syncytial virus; respiratory syncytial virus (RSV); Respiratory tract infection; Respiratory Tract Infections - epidemiology; Respiratory Tract Infections - virology; Seasons; severe acute respiratory infection; Severe acute respiratory syndrome coronavirus 2; Statistical analysis; Surveillance; Thermal cycling; under 5 children; Viral infections; Viruses; Viruses - classification; Viruses - genetics; Viruses - isolation & purification
• ISSN: 1999-4915; 1999-4915
• DOI: 10.3390/v17010027

Acute respiratory infections (ARIs) are a leading cause of death in children under five globally. The seasonal trends and profiles of respiratory viruses vary by region and season. Due to limited information and the population's vulnerability, we conducted the hospital-based surveillance of respiratory viruses in Eastern Uttar Pradesh. Throat and nasal swabs were collected from outpatients and inpatients in the Department of Paediatrics, Baba Raghav Das (BRD) Medical College, Gorakhpur, between May 2022 and April 2023. A total of 943 samples from children aged 1 to 60 months were tested using multiplex real-time PCR for respiratory viruses in cases of ARI and SARI. Out of 943 samples tested, the highest positivity was found for parainfluenza virus [105 (11.13%) PIV-1 (79), PIV-2 (18), PIV-4 (18)], followed by adenovirus [82 (8.7%), RSV-B, [68 (7.21%)], influenza-A [46(4.9%): H1N1 = 29, H3N2 = 14), SARS CoV-2 [28 (3%)], hMPV [13(1.4%), RSV-A [4 (0.42%), and influenza-B (Victoria lineage) 1 (0.10%). The maximum positivity of respiratory viruses was seen in children between 1 to 12 months. The wide variation in prevalence of these respiratory viruses was seen in different seasons. This study enhances understanding of the seasonal and clinical trends of respiratory virus circulation and co-infections in Eastern Uttar Pradesh. The findings highlight the importance of targeted interventions to reduce the burden of respiratory infections in this region.