Effect of atorvastatin gel in non-surgical treatment of peri-implant mucositis: A randomized controlled clinical trial

Peri-implant diseases, such as peri-implant mucositis and peri-implantitis, are inflammatory conditions caused by biofilms that can lead to the loss of surrounding soft tissues and bone. The most effective treatment involves non-surgical mechanical debridement to remove plaque, but other treatment m...

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Published in:Journal of advanced periodontology and implant dentistry 2024-09, Vol.16 (2), p.116-122
Main Authors: Khorramdel, Azin, Mogharrab Alile, Katayoun, Kananizadeh, Yousef, Mousavi, Seyed Amin, Molavi, Fatima
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Mogharrab Alile, Katayoun
Kananizadeh, Yousef
Mousavi, Seyed Amin
Molavi, Fatima
description Peri-implant diseases, such as peri-implant mucositis and peri-implantitis, are inflammatory conditions caused by biofilms that can lead to the loss of surrounding soft tissues and bone. The most effective treatment involves non-surgical mechanical debridement to remove plaque, but other treatment modalities have shown limited success. This study investigated the anti-inflammatory and immunomodulatory effects of atorvastatin (ATV) gel as an additional treatment for peri-implant mucositis. In this double-masked, randomized clinical trial, 49 patients with peri-implant mucositis were randomly divided into two treatment groups: mechanical debridement (MD)+placebo or MD+ATV gel. At baseline, 1 month, and 3 months after the intervention, periodontal parameters, including probing depth (PD), bleeding on probing (BOP), clinical attachment level (CAL), and pain on probing (POP), were measured. Data were analyzed using independent t-test and paired t-test. Statistically significant improvements in CAL and POP were observed from baseline to each time point throughout the study period ( ≤0.001). PD and BOP were statistically significant 1 month and 3 months after the intervention, respectively (
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title Effect of atorvastatin gel in non-surgical treatment of peri-implant mucositis: A randomized controlled clinical trial
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