Formation of neuron-microelectrode junction mediated by a synapse organizer

Neural circuits are composed of various cell types, each of which is thought to play a specific role in realizing the circuit functions. Cell-type specificity is therefore essential in recording neuronal activities but is inherently lacking in the currently available microelectrode techniques. Here,...

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Bibliographic Details
Published in:Applied physics express 2023-05, Vol.16 (5), p.57003
Main Authors: Kim, Samyoung, Imayasu, Mieko, Yoshida, Tomoyuki, Tsutsui, Hidekazu
Format: Article
Language:English
Subjects:
microelectrode
neural circuit
neuron
synapse organizer
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Summary:Neural circuits are composed of various cell types, each of which is thought to play a specific role in realizing the circuit functions. Cell-type specificity is therefore essential in recording neuronal activities but is inherently lacking in the currently available microelectrode techniques. Here, using Interleukin-1 receptor accessory protein-like 1 (IL1RAPL1) as a model synapse organizer, we show a proof-of-principle experiment that a microelectrode functionalized with a synapse organizer is capable of inducing a synapse-like junction between a neuron upon physical contact. We then discuss prospects for developing a new mode of electrophysiology that permits cell-type specific recordings via such a molecularly induced neuron-microelectrode junction.
ISSN:1882-0778
1882-0786
DOI:10.35848/1882-0786/acd166