Ophiopogonin D Represses Transforming Growth Factor-β1-Induced Proliferation and Inflammation of Airway Smooth Muscle Cells by Inhibiting P65/Adenosine 5'-Monophosphate-Activated Protein/Nuclear Factor-Kappa B Signaling Pathway

Asthma, a common disease in children, is associated with proliferation and inflammation of airway smooth muscle cells. Ophiopogonin D is a bioactive steroid glycoside derived from the Japanese japonica rice root that has been shown to exhibit multiple biological activities through its antioxidant an...

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Bibliographic Details
Published in:Current topics in nutraceuticals research 2021-06, Vol.19 (4), p.537-542
Main Authors: Liu, Shan, Yu, Chunqing
Format: Article
Language:English
Online Access:Get full text
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Summary:Asthma, a common disease in children, is associated with proliferation and inflammation of airway smooth muscle cells. Ophiopogonin D is a bioactive steroid glycoside derived from the Japanese japonica rice root that has been shown to exhibit multiple biological activities through its antioxidant and anti-inflammatory properties. Herein, we report that ophiopogonin D inhibits TGF-β1-induced proliferation of airway smooth muscle cells through suppression of p65/AMPK/NF-κB pathway. We therefore conclude that ophiopogonin D is a promising candidate therapeutic drug for childhood asthma treatment.
ISSN:1540-7535
DOI:10.37290/ctnr2641-452X.19:537-542