Isofraxidin Protects BV2 Cells from Oxygen and Glucose Deprivation Injury via Regulating NF-κB/NLRP3 Pathway

Inflammation is a significant contributor to ischemic stroke. Isofraxidin has been demonstrated to play an anti-inflammatory role in different diseases. However, its role in cerebral ischemia injury still needs to be explored. Using BV2 cells subjected to oxygen and glucose deprivation as a model fo...

Full description

Saved in:
Bibliographic Details
Published in:Current topics in nutraceuticals research 2022-08, Vol.20 (3), p.535-543
Main Authors: Su, Ying, Chen, Yang, Hou, Shuangxing, Ye, Jun
Format: Article
Language:English
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Inflammation is a significant contributor to ischemic stroke. Isofraxidin has been demonstrated to play an anti-inflammatory role in different diseases. However, its role in cerebral ischemia injury still needs to be explored. Using BV2 cells subjected to oxygen and glucose deprivation as a model for cerebral ischemia injury, we have shown that isofraxidin treatment alleviates cell injury and apoptosis, reduces inflammation, and decreases oxidative stress by suppressing NF-κB/NLRP3 pathway.
ISSN:1540-7535
DOI:10.37290/ctnr2641-452X.20:535-543