SO 2 F 2 -mediated transformation of 2'-hydroxyacetophenones to benzo-oxetes

A catalyst-free novel and efficient methodology for the challenging synthesis of benzo-oxetes from 2'-hydroxyacetophenones mediated by sulfuryl fluoride (SO F ) gas has been realized. The combination of 2'-hydroxyacetophenones and SO F furnishes synthetically challenging benzo-oxetanes in...

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Bibliographic Details
Published in:Beilstein journal of organic chemistry 2019-04, Vol.15, p.976-980
Main Authors: Lekkala, Revathi, Lekkala, Ravindar, Moku, Balakrishna, Rakesh, K P, Qin, Hua-Li
Format: Article
Language:English
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Summary:A catalyst-free novel and efficient methodology for the challenging synthesis of benzo-oxetes from 2'-hydroxyacetophenones mediated by sulfuryl fluoride (SO F ) gas has been realized. The combination of 2'-hydroxyacetophenones and SO F furnishes synthetically challenging benzo-oxetanes in moderate to excellent yields. The highlight of this work is the design and synthesis of strained four-membered oxete rings.
ISSN:1860-5397
1860-5397
DOI:10.3762/bjoc.15.95