Dynamic and Scintigraphic Studies of Diffuse Hepatic Diseases Using 99mTc-Sn-phytate (Comparative Analyses with 198 Au-colloid)

• Published in: RADIOISOTOPES 1975/09/15, Vol.24(9), pp.626-632
• Main Authors: AKISADA, Masayoshi, MIYAMAE, Tatsuya
• Format: Article
• Language: eng ; jpn
• ISSN: 0033-8303; 1884-4111
• DOI: 10.3769/radioisotopes.24.9_626

From March 1974 to May 1974, liver scintigraphies were performed in Mitsui Memorial Hospital. Three groups of patients were composed of 24 of liver cirrhosis, 29 of chronic hepatitis and 30 of normal control group. The mixture of 1.5 mCi of99mTc-phytate and 30μCi of198Au-colloid were injected rapidly. 1) KLvalue of99mTc-phytate in liver cirrhosis group was smaller than normal group and between them, chronic hepatitis group existed. 2) The correlation between T1/2 (L) and T1/2 (P) : In normal group, the coefficient correlation between T1/2 (L) and T1/2 (P) was fairly good both in99mTc-phytate and in198Au-colloid, whereas the correlation was low in chronic hepatitis group and liver cirrhosis group. 3) The correlation of KLvalue between99mTc-phytate and198Au-colloid: The correlation of KLvalue were low in all three groups: however, KLvalues in99mTc-phytate were higher than in198Au-colloid in all three groups. 4) When each probe was placed on the temporal and thigh region simultaneously for obtaining the peripheral blood clearance, T1/2 (P) value (temporal) was always smaller than T1/2 (P) value (thigh) . 5) Grade of kidney visualization in liver scintigraphy using99mTc-phytate: Kidney activities were seen in 72.9% of 83 patients and there was no grade difference between normal, chronic hepatitis and liver cirrhosis group. 6) An additional attempt to determine the nature and size of“99mTc-phytate in vivo colloid”, Ca ion was added to99mTc-phytate solution prior to the injection. Lung, spleen, and liver were simultaneously visualized using this“in vitro99mTc-phytate minicolloid”.