Stereoelectroencephalography is useful for detecting the spatiotemporal dynamics of auditory namingrelated high-gamma modulations

• Published in: Epilepsy & Seizure 2023, Vol.15(1), pp.82-94
• Main Authors: Mitsuhashi, Takumi, Iimura, Yasushi, Suzuki, Hiroharu, Ueda, Tetsuya, Nishioka, Kazuki, Nomura, Kazuki, Nakajima, Madoka, Sugano, Hidenori, Kondo, Akihide
• Format: Article
• Language: English
• Subjects: Auditory naming; Event-related high-gamma modulation; Four-dimensional; Intracranial electroencephalography; Speech; Stereoelectroencephalography
• ISSN: 1882-5567; 1882-5567
• DOI: 10.3805/eands.15.82

Purpose: To determine the utility of stereoelectroencephalography (SEEG) in detecting the spatiotemporal dynamics of auditory naming-related high-gamma modulation.Methods: This cross-sectional study investigated eight patients with drug-resistant focal epilepsy who performed an auditory naming task with vocal responses during SEEG recording. We generated time-frequency plots and animation videos delineating the dynamics of auditory naming-related high-gamma activity at 60-140 Hz.Results: Auditory naming elicited high-gamma augmentation in the bilateral superior temporal gyri, insula, left triangular part of the inferior frontal gyrus, precentral gyrus, and right lateral occipital complex between 160 and 210 ms after stimulus onset, followed by the right cuneus after 1080 ms. Augmentation in the bilateral superior temporal gyri continued during stimulus presentation. Around the stimulus offset, the left precentral gyrus showed reaugmentation, followed by the right lingual gyrus and bilateral superior temporal gyri. Frontotemporal activation was consistent with the results of previous electrocorticography (ECoG) studies. These studies did not detect any activity in the insula associated with auditory naming.Conclusion: This study demonstrated the utility of SEEG for analyzing high-gamma modulations by replicating the spatiotemporal dynamics determined in previous ECoG studies. Compared to ECoG, SEEG may be beneficial for detecting high-gamma modulations in deep brain structures such as the insula.