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Neoadjuvant Gemcitabine Therapy for Breast Cancer
Neoadjuvant chemotherapy has become a standard treatment in the management of locally advanced breast cancer. Patients with earlier-stage disease may also benefit from neoadjuvant treatment in terms of improved rates of breast-conserving surgery and thus better quality of life. Gemcitabine is a pyri...
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Published in: | Clinical breast cancer 2002-05, Vol.3, p.S39-S44 |
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container_end_page | S44 |
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container_start_page | S39 |
container_title | Clinical breast cancer |
container_volume | 3 |
creator | Sánchez-Rovira, Pedro Jaén, Ana Dueñas, Rosario Porras, Ignacio Martínez, Esther Medina, Begoña Mohedano, Nicolás Fernández, Margarita Lozano, Ana |
description | Neoadjuvant chemotherapy has become a standard treatment in the management of locally advanced breast cancer. Patients with earlier-stage disease may also benefit from neoadjuvant treatment in terms of improved rates of breast-conserving surgery and thus better quality of life. Gemcitabine is a pyrimidine analogue that has shown activity in a variety of solid tumors, a good toxicity profile, and nonoverlapping toxicity with other chemotherapeutic agents. Several phase II/III studies are assessing gemcitabine combined with anthracyclines, taxanes, and/or vinorelbine both in the neoadjuvant and metastatic disease settings. This article reviews developments in neoadjuvant use of gemcitabine in combination with anthracyclines and taxanes. Several phase II trials of gemcitabine combined with doxorubicin/epirubicin or with doxorubicin/paclitaxel have been carried out. Preliminary findings demonstrate increased complete response rates and good tolerability of these regimens in patients with breast cancer. |
doi_str_mv | 10.3816/CBC.2002.s.009 |
format | article |
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Patients with earlier-stage disease may also benefit from neoadjuvant treatment in terms of improved rates of breast-conserving surgery and thus better quality of life. Gemcitabine is a pyrimidine analogue that has shown activity in a variety of solid tumors, a good toxicity profile, and nonoverlapping toxicity with other chemotherapeutic agents. Several phase II/III studies are assessing gemcitabine combined with anthracyclines, taxanes, and/or vinorelbine both in the neoadjuvant and metastatic disease settings. This article reviews developments in neoadjuvant use of gemcitabine in combination with anthracyclines and taxanes. Several phase II trials of gemcitabine combined with doxorubicin/epirubicin or with doxorubicin/paclitaxel have been carried out. 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subjects | Antineoplastic Combined Chemotherapy Protocols - therapeutic use Breast Neoplasms - drug therapy Breast Neoplasms - pathology Clinical Trials, Phase II as Topic Deoxycytidine - administration & dosage Deoxycytidine - analogs & derivatives Doxorubicin Doxorubicin - administration & dosage Epirubicin Epirubicin - administration & dosage Female Gemcitabine HER2/ neu overexpression Humans Neoadjuvant Therapy Neoplasm Metastasis Neoplasm Recurrence, Local Paclitaxel - administration & dosage Taxanes Treatment Outcome |
title | Neoadjuvant Gemcitabine Therapy for Breast Cancer |
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