Cognitive Dysfunction and Chemotherapy: Neuropsychological Findings in Perspective

Currently, the interest in cognitive functioning following chemotherapy is rapidly expanding as is reflected in a growing number of published studies on this topic. Although most studies are indicative of cognitive deficits after chemotherapy, definite conclusions on the role of chemotherapy on cogn...

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Bibliographic Details
Published in:Clinical breast cancer 2002-12, Vol.3, p.S100-S108
Main Authors: Schagen, Sanne B., Muller, Martin J., Boogerd, Willem, van Dam, Frits S.A M.
Format: Article
Language:English
Subjects:
Adjuvant chemotherapy
Antineoplastic Combined Chemotherapy Protocols - adverse effects
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Breast cancer
Breast Neoplasms - diagnosis
Breast Neoplasms - drug therapy
Breast Neoplasms - surgery
Central Nervous System - drug effects
Chemotherapy, Adjuvant - adverse effects
Cognition
Cognition Disorders - chemically induced
Cognition Disorders - diagnosis
Cognition Disorders - epidemiology
Dose-Response Relationship, Drug
Drug Administration Schedule
Female
Humans
Incidence
Mastectomy - methods
Neurologic Examination
Neuropsychological Tests
Neuropsychology
Prognosis
Risk Assessment
Severity of Illness Index
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Summary:Currently, the interest in cognitive functioning following chemotherapy is rapidly expanding as is reflected in a growing number of published studies on this topic. Although most studies are indicative of cognitive deficits after chemotherapy, definite conclusions on the role of chemotherapy on cognitive function can often not be drawn due to methodological problems. On the basis of the studies on cognitive functioning after chemotherapy that are conducted in The Netherlands Cancer Institute, the current article describes a number of such methodological topics that obscure straightforward interpretation of neuropsychological findings in toxicity research. Measurement issues that diverge from usual assessment issues encountered in psychosocial oncology will be described, and factors that might play a role in the cause of cognitive impairment will be evaluated. Also, future developments necessary to gain more insight into the prevalence, the pattern, and the impact of cognitive problems following chemotherapy are discussed.
ISSN:1526-8209
1938-0666
DOI:10.3816/CBC.2002.s.020