ITPase activity modulates the severity of anaemia in HCV-related cirrhosis treated with ribavirin-containing interferon-free regimens

To investigate the association between inosine triphosphatase (ITPase) activity and the degree of anaemia occurring during direct-acting antiviral (DAA)/ribavirin (RBV)-based therapy in patients with cirrhosis. In a multicentre, prospective study 227 patients with HCV-related cirrhosis treated with...

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Bibliographic Details
Published in:Antiviral therapy 2017-01, Vol.22 (7), p.551-558
Main Authors: Coppola, Nicola, De Pascalis, Stefania, Messina, Vincenzo, Di Caprio, Giovanni, Martini, Salvatore, de Stefano, Giorgio, Starace, Mario, Stornaiuolo, Gianfranca, Stanzione, Maria, Ascione, Tiziana, Minichini, Carmine, Sangiovanni, Vincenzo, Zampino, Rosa, Calò, Federica, Rinaldi, Luca, Persico, Marcello, Federico, Alessandro, Buonomo, Antonio Riccardo, Borgia, Guglielmo, Gaeta, Giovanni Battista, Filippini, Pietro, Gentile, Ivan
Format: Article
Language:English
Subjects:
Aged
Alleles
Anemia - diagnosis
Anemia - etiology
Anemia - metabolism
Antiviral Agents - adverse effects
Antiviral Agents - therapeutic use
Disease Susceptibility
Drug Therapy, Combination
Enzyme Activation
Female
Gene Frequency
Genotype
Hepatitis C, Chronic - complications
Hepatitis C, Chronic - drug therapy
Humans
Inosine Triphosphatase
Liver Cirrhosis - complications
Liver Cirrhosis - etiology
Male
Middle Aged
Odds Ratio
Polymorphism, Single Nucleotide
Pyrophosphatases - genetics
Pyrophosphatases - metabolism
Ribavirin - adverse effects
Ribavirin - therapeutic use
Risk Factors
Severity of Illness Index
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Summary:To investigate the association between inosine triphosphatase (ITPase) activity and the degree of anaemia occurring during direct-acting antiviral (DAA)/ribavirin (RBV)-based therapy in patients with cirrhosis. In a multicentre, prospective study 227 patients with HCV-related cirrhosis treated with DAA and RBV were enrolled. All patients were screened for the rs1127354 and rs7270101 ITPA single nucleotide polymorphisms using direct sequencing. 150 (66.1%) patients had normal (100%) ITPase activity, 48 (21.1%) had moderate (60%) activity and 29 (12.8%) minimal (≤30%) activity. The ITPase activity significantly influenced the haemoglobin concentration: at day 15 it was -1.248 (sd ±0.978) in the 150 patients with an ITPase activity of 100% and -0.616 (±0.862) in the 77 patients with an ITPase activity less than 100% (P
ISSN:1359-6535
2040-2058
DOI:10.3851/IMP3134