Multiple Trauma with Persistently High Serum Levels of (1→3)-β-D-Glucan Even after Amelioration of SIRS

We report the case of a 28 year-old man with multiple trauma who had persistently high serum levels of (1→3)-β-D-glucan (7, 400pg/ml) even after the state of systemic inflammatory response syndrome (SIRS) subsided. This finding suggests that the serum level of (1→3)-β-D-glucan dose not always reflec...

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Bibliographic Details
Published in:Nihon Kyukyu Igakukai Zasshi 2000/05/15, Vol.11(5), pp.237-242
Main Authors: Kamio, Hitoshi, Mato, Takashi, Shiga, Hajime, Tsutsumi, Haruhiko, Wakabayashi, Toshio, Omura, Masao
Format: Article
Language:English
Subjects:
(1→3)-β-D-glucan
multiple trauma
mycosis
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Summary:We report the case of a 28 year-old man with multiple trauma who had persistently high serum levels of (1→3)-β-D-glucan (7, 400pg/ml) even after the state of systemic inflammatory response syndrome (SIRS) subsided. This finding suggests that the serum level of (1→3)-β-D-glucan dose not always reflect the state of illness nor serve as a guide for treatment. This case did not show any findings of intestinal fungal infection, but the state of SIRS subsided after enteral medication of amphotericin B. Several oral medications and enteral diets were found to contain a significant amount of (1→3)-β-D-glucan, so we hypothesized that fungi or (1→3)-β-D-glucan had translocated from the intestines to the blood.
ISSN:0915-924X
1883-3772
DOI:10.3893/jjaam.11.237