Septic ARDS and Gram-positive Bacteremia in which TSST-1 was Detected in a Cervical Abscess

Toxic-shock syndrome is an acute-onset, multiorgan illness that resembles severe scarlet fever. Superantigen activates a huge number of T-cells by linkage to a particular V βelement of the T-cell receptor, which directly associates with major histocompatibility complex (MHC) class II molecules. We r...

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Bibliographic Details
Published in:Nihon Kyukyu Igakukai Zasshi 2002/02/15, Vol.13(2), pp.67-72
Main Authors: Ikeda, Toshiaki, Fukuyama, Mayumi, Miwa, Takashi, Ikeda, Kazumi, Oohashi, Hiroki, Sakurai, Jun
Format: Article
Language:English
Subjects:
respiratory index
superantigen
TSST-1
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Summary:Toxic-shock syndrome is an acute-onset, multiorgan illness that resembles severe scarlet fever. Superantigen activates a huge number of T-cells by linkage to a particular V βelement of the T-cell receptor, which directly associates with major histocompatibility complex (MHC) class II molecules. We report a 64-year-old man with superantigen toxic shock syndrome toxin-1 (TSST-1), who had severe hypoxemia caused by airway stenosis and septic shock due to a cervical abscess. He underwent emergency tracheostomy and cervical incision to remove the abscess. Septic ARDS developed despite intensive care. Here, septic ARDS refers to the respiratory index (R-index: A-aDO2/PaO2) increasing to 5.57 on day 10 in the ICU. Changes in TSST-1 were similar to the R-index. No correlation was seen between IL-6 and serum TSST-1 antigen during the ICU period, but a statistically significant correlation (r=0.813, p
ISSN:0915-924X
1883-3772
DOI:10.3893/jjaam.13.67