Prevention of Drug and Poison Absorption in Poisoning via Ingestion

It is a common practice to try to prevent gastro-intestinal absorption of ingested poisons. Controversy continues about the relative effectiveness of charcoal, ipecacuarha and gastric lavage in salicylate overdose. Until the 1980's there were only a few experimental or clinical human studies on...

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Bibliographic Details
Published in:Nihon Kyukyu Igakukai Zasshi 1997/07/15, Vol.8(7), pp.273-287
Main Authors: Yamashita, Mamoru, Tanaka, Junsuke, Yamashita, Masatomo
Format: Article
Language:English
Subjects:
activated charcoal
emesis
gastric lavage
multiple doses of charcoal therapy
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Summary:It is a common practice to try to prevent gastro-intestinal absorption of ingested poisons. Controversy continues about the relative effectiveness of charcoal, ipecacuarha and gastric lavage in salicylate overdose. Until the 1980's there were only a few experimental or clinical human studies on the antidotal effect of high doses of activated charcoal. Recently, the effect of high single and repeated dose of charcoal on absorption and elimination of various drugs has been studied intensively. The role of multiple doses of charcoal therapy in acute intoxication has been clearly defined.
ISSN:0915-924X
1883-3772
DOI:10.3893/jjaam.8.273