Effects of Total Parenteral Nutrition (TPN) Supplemented with Medium-Chain Triglyceride (MCT) in Rats with Endotoxin-Induced Sepsis

• Published in: Nihon Kyukyu Igakukai Zasshi 1997/07/15, Vol.8(7), pp.288-296
• Main Authors: Iba, Toshiaki, Yagi, Yoshihiro, Kidokoro, Akio, Fuse, Syoichi, Ohno, Yoichi, Kaneshiro, Yoshiaki, Akiyama, Tadashi
• Format: Article
• Language: English
• Subjects: bacterial translocation; endotoxin; medium-chain triglyceride (MCT); rat; total parenteral nutrition (TPN)
• ISSN: 0915-924X; 1883-3772
• DOI: 10.3893/jjaam.8.288

Although lipid is a superior energy source, long-chain triglyceride (LCT) has not been used in septic patients because of its side effects, such as hepatotoxicity and blockade of the reticuloendothelial system. In this study, we evaluated the usefulness of medium-chain triglyceride (MCT) in the treatment of septic rats. Materials and Methods: Rats were fasted and subjected to either fat-free TPN, TPN with LCT, or TPN with MCT. In the fat-treated group, half of the non-protein calories were administered in the form of LCT or MCT. On day 4, 0.8mg/kg or 0.05mg/kg of endotoxin was injected intravenously and survival rates were calculated. In the other study, 0.05mg/kg of endotoxin was injected and 24hrs later blood samples were collected, and at the same time, bacterial translocation (BT) from the gut to the mesenteric lymph nodes, liver and systemic blood was measured. Results: The survival rate was significantly higher in the MCT group (p