Inhibition of carrageenan-induced edema by tripleurospermum disciforme extract in rats

In this research anti-inflammatory effect of Tripleurospermum disciforme extract was studied in rats. The effect of the extract against acute inflammation was studied by hind paw edema test. Intraperitoneal injection of different doses (15, 30, 45, 60, 90 and 120 mg kg(-1)) of Tripleurospermum disci...

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Published in:Pakistan journal of biological sciences 2007-07, Vol.10 (13), p.2237-2240
Main Authors: Bakhtiarian, Azam, Ejtemaimehr, Shahram, Strobl, Sylvia, Pournaghash-Tehrani, Said, Partoazar, Alireza, Ghamami, Guiti, Yasa, Narges
Format: Article
Language:English
Subjects:
Animals
Anti-Inflammatory Agents - pharmacology
Carrageenan - antagonists & inhibitors
Carrageenan - toxicity
Dose-Response Relationship, Drug
Edema - chemically induced
Edema - prevention & control
Indomethacin - pharmacology
Plant Extracts - pharmacology
Rats
Rats, Sprague-Dawley
Tripleurospermum - chemistry
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Summary:In this research anti-inflammatory effect of Tripleurospermum disciforme extract was studied in rats. The effect of the extract against acute inflammation was studied by hind paw edema test. Intraperitoneal injection of different doses (15, 30, 45, 60, 90 and 120 mg kg(-1)) of Tripleurospermum disciforme which was followed by hind paw carageenan injection 1 h later were investigated. The resultant edema was quantified by measuring changes of diameter of hind foot. After 2, 3, 4 and 6 h we measured the anti-inflammatory effect of Tripleurospermum disciforme extract. Tripleurospermum disciforme extract with doses of 45, 60, 90 and 120 mg kg(-1) and indomethacin 5 mg kg(-1) showed significant effect. It is concluded that Tripleurospermum disciforme extract has anti-inflammatory effect against acute inflammation.
ISSN:1028-8880
DOI:10.3923/pjbs.2007.2237.2240