Haptoglobin inhibits the pro-inflammatory activity of HMGB1 (P4177)

HMGB1 is a cytokine mediator in the pathogenesis of inflammatory diseases including sepsis (Yang et al, BBA, 2009). Recently we demonstrated that haptoglobin (Hp), a naturally occurring serum protein, binds to HMGB1 and suppresses HMGB1-stimulated TNF and IL-8 release in cultured macrophages. Hp kno...

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Bibliographic Details
Published in:The Journal of immunology (1950) 2013-05, Vol.190 (1_Supplement), p.112-112.22
Main Authors: Yang, Huan, Ju, Zhongliang, Lu, Ben, Ochani, Mahendar, Li, Jianhua, Chavan, Sangeeta, Tracey, Kevin
Format: Article
Language:English
Online Access:Get full text
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Summary:HMGB1 is a cytokine mediator in the pathogenesis of inflammatory diseases including sepsis (Yang et al, BBA, 2009). Recently we demonstrated that haptoglobin (Hp), a naturally occurring serum protein, binds to HMGB1 and suppresses HMGB1-stimulated TNF and IL-8 release in cultured macrophages. Hp knockout mice subjected to cecal ligation and puncture (CLP)-induced sepsis had significantly higher serum HMGB1 levels and higher mortality rates compared to wild type animals (75% survival in wild type vs. 34% in Hp knockout mice; P
ISSN:0022-1767
1550-6606
DOI:10.4049/jimmunol.190.Supp.112.22