Racial disparities in the vitamin D-mediated innate immune response following supplementation (P3379)

• Published in: The Journal of immunology (1950) 2013-05, Vol.190 (1_Supplement), p.202-202.12
• Main Authors: Reyes, Rachel, Rafison, Brandon, Hur, Andy, Joyce, Peter, Modlin, Robert, Liu, Philip, Adams, John
• Format: Article
• Language: English
• ISSN: 0022-1767; 1550-6606
• DOI: 10.4049/jimmunol.190.Supp.202.12

We have previously demonstrated that innate (Toll-like receptor 2/1) and adaptive (IFN-γ) immune signals converge on a common vitamin D-dependent antimicrobial pathway in the human macrophage against Mycobacterium tuberculosis, including activation of CYP27B1 which converts 25D into the active 1,25D hormone as well as expression of antimicrobial peptides cathelicidin and human beta defensin 4. This antimicrobial activity is dependent on the level of extracellular 25D in culture. Therefore, we asked if this antimicrobial response could be recapitulated using sera from 25D deficient subjects before and after vitamin D repletion of the host in vivo. Serum has been collected prospectively from 67 Hispanic/Latino, 12 black and 21 non-Hispanic white, vitamin D-insufficient/deficient (8-29 ng/ml) before and after treatment with 500,000 IU vitamin D3. The mean total serum 25D in all three ethnic groups was 20ng/ml before and rose significantly (p