Impaired lymphocyte response in patients with chronic kidney disease (P3075)

In Chronic Kidney Disease (CKD), immune cells are affected due to uremic toxins. Given the central role of T lymphocytes in the progress of CKD, we analyzed lymphocyte proliferative response and immune modulators production to selected stimulators. We applied a method called Flow-cytometric Assay fo...

Full description

Saved in:
Bibliographic Details
Published in:The Journal of immunology (1950) 2013-05, Vol.190 (1_Supplement), p.43-43.3
Main Authors: Mansouri, Ladan, Lundahl, Joachim, Jacobson, Stefan, Paulsson, Josefin
Format: Article
Language:English
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In Chronic Kidney Disease (CKD), immune cells are affected due to uremic toxins. Given the central role of T lymphocytes in the progress of CKD, we analyzed lymphocyte proliferative response and immune modulators production to selected stimulators. We applied a method called Flow-cytometric Assay for Specific Cell-mediated Immune-response in Activated whole blood (FASCIA) using whole blood and flow-cytometric analysis for detection of proliferation in addition to a multi-array method (Milliplex 26-plex) to analyze the profile of immune modulators. The absolute number of lymphoblasts, CD4+, CD8+ subpopulations in response to mitogens were equal comparing healthy controls, patients with eGFR
ISSN:0022-1767
1550-6606
DOI:10.4049/jimmunol.190.Supp.43.3