Complement C3 increases cardiomyocyte resistance to apoptosis in response to hypoxia

Hypoxia takes places in pathogenic conditions, such as heart ischemia. Complements factors have been reported to play an important role in ischemia-reperfusion injury in various animal models. We studied the cellular response to complement under hypoxia condition using a human cardiomyocyte cell lin...

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Bibliographic Details
Published in:The Journal of immunology (1950) 2019-05, Vol.202 (1_Supplement), p.126-126.12
Main Authors: Fang, Zhou, Li, Xiang, Xu, Fou, Elvington, Michelle, Kulkarni, Hrishikesh, Atkinson, John P., Zhang, Ming
Format: Article
Language:English
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Summary:Hypoxia takes places in pathogenic conditions, such as heart ischemia. Complements factors have been reported to play an important role in ischemia-reperfusion injury in various animal models. We studied the cellular response to complement under hypoxia condition using a human cardiomyocyte cell line AC16. Under hypoxia condition without serum (thus no exogenous complements provided), these cardiomyocytes underwent apoptosis. However, when pure human C3 was supplemented after hypoxia, these cells had less apoptosis and maintained a reasonable survival rate. The results indicate that complement C3 can increase the cardiomyocytes resistance to apoptosis under the hypoxia condition.
ISSN:0022-1767
1550-6606
DOI:10.4049/jimmunol.202.Supp.126.12