Detection and characterisation of lung-resident memory T cells in human and non-human primates

Rationale: Lung-resident memory T cells (TRM) play a critical role in protecting against respiratory infection. Maintained in a quiescent state, TRM are poised for rapid effector function upon reactivation with cognate antigen. Kronoscan is a clinic-ready, fibre-based, optical imaging system develop...

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Bibliographic Details
Published in:The Journal of immunology (1950) 2021-05, Vol.206 (1_Supplement), p.26-26.09
Main Authors: Humphries, Duncan Charles, O‘Connor, Richard, Chabaud-Riou, Martine, Boudet, Florence, Finlayson, Keith, Dhaliwal, Kevin, Pavot, Vincent
Format: Article
Language:English
Online Access:Get full text
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Summary:Rationale: Lung-resident memory T cells (TRM) play a critical role in protecting against respiratory infection. Maintained in a quiescent state, TRM are poised for rapid effector function upon reactivation with cognate antigen. Kronoscan is a clinic-ready, fibre-based, optical imaging system developed by the University of Edinburgh, capable of measuring both fluorescence intensity and lifetime. The aim of this study is to develop a staining protocol to enable the detection of human and non-human primate (NHP) pulmonary TRM populations in situ.
ISSN:0022-1767
1550-6606
DOI:10.4049/jimmunol.206.Supp.26.09