Extracellular immune checkpoint molecules released from HTLV-1-infected cells mount immune suppression in the context of neuroinflammation

HTLV associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a chronic, progressive neuroinflammatory demyelinating condition of the spinal cord. We have previously shown that aberrant expression and activity of immune checkpoint (ICP) molecules – PD-1/PD-L1, negatively associates with the c...

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Bibliographic Details
Published in:The Journal of immunology (1950) 2023-05, Vol.210 (1_Supplement), p.59-59.39
Main Authors: Joseph, Julie, Premeaux, Thomas, Pinto, Daniel O, Rao, Ahbishek, Guha, Shrobona, Panfil, Amanda, Carey, Alison, Ndhlovu, Lishomwa, Bergmann-Leitner, Elke, Jain, Pooja
Format: Article
Language:English
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Summary:HTLV associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a chronic, progressive neuroinflammatory demyelinating condition of the spinal cord. We have previously shown that aberrant expression and activity of immune checkpoint (ICP) molecules – PD-1/PD-L1, negatively associates with the cytolytic potential of T cells in individuals with HAM/TSP. Interestingly, ICPs can exist in soluble cell-free form and can be carried on extracellular vesicles (EV) and exosomes (small EVs,
ISSN:0022-1767
1550-6606
DOI:10.4049/jimmunol.210.Supp.59.39