Adenosine A 2A Receptor and IL-10 in Peripheral Blood Mononuclear Cells of Patients with Mild Cognitive Impairment

Adenosine suppresses immune responses through the A 2A receptor (A 2A R). This study investigated the interleukin 10 (IL-10) genetic profile and the expression of A 2A R in peripheral blood mononuclear cells (PBMCs) of patients with mild cognitive impairment (MCI), Alzheimer disease (AD), and age-ma...

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Bibliographic Details
Published in:International journal of alzheimer's disease 2011, Vol.2011, p.1-6
Main Authors: Arosio, Beatrice, Mastronardi, Luigina, Gussago, Cristina, Nicolini, Paola, Casè, Alessandra, Ziglioli, Eleonora, Bergamaschini, Luigi
Format: Article
Language:English
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Summary:Adenosine suppresses immune responses through the A 2A receptor (A 2A R). This study investigated the interleukin 10 (IL-10) genetic profile and the expression of A 2A R in peripheral blood mononuclear cells (PBMCs) of patients with mild cognitive impairment (MCI), Alzheimer disease (AD), and age-matched controls to verify, if they may help distinguish different forms of cognitive decline. We analyzed the IL-10 genotype and the expression of A 2A R in 41 subjects with AD, 10 with amnestic MCI (a-MCI), 49 with multiple cognitive domain MCI (mcd-MCI), and 46 controls. There was a significant linear increase in A 2A R mRNA levels and A 2A R density from mcd-MCI to a-MCI, with intermediate levels being found in AD. The IL-10 AA genotype frequency was 67% in a-MCI, 46% in AD, 35% in mcd-MCI, and 20% in controls. These data suggest that the assessment of the IL-10 genotype and the expression of A 2A R in PBMCs may be a valuable means of differentiating between a-MCI and mcd-MCI.
ISSN:2090-0252
2090-0252
DOI:10.4061/2011/484021