Hormonal profile of survivors of breast cancer with fatigue: A pilot study

Background & objectives: One of the most common problems experienced by breast cancer survivors (BCSs) is fatigue. There has been little research about the status of hormones in breast cancer patients as an aetiology of cancer-related fatigue (CRF). Hence, a pilot study was conducted to assess t...

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Bibliographic Details
Published in:Indian Journal of Medical Research 2023-04, Vol.157 (4), p.358-362
Main Authors: Gupta, Shardool, Kaur, Navneet, Madhu, S
Format: Article
Language:English
Subjects:
Breast cancer
Complications and side effects
Endocrine gland diseases
Fatigue
Health aspects
Hormones
Measurement
Patient outcomes
Pilot projects
Practice: Short Paper
Risk factors
Thyroid gland
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Summary:Background & objectives: One of the most common problems experienced by breast cancer survivors (BCSs) is fatigue. There has been little research about the status of hormones in breast cancer patients as an aetiology of cancer-related fatigue (CRF). Hence, a pilot study was conducted to assess the levels of hormones such as thyroid, cortisol, dehydroepiandrosterone sulphate (DHEAS), oestrogen and progesterone in BCSs with fatigue. Methods: BCSs with complaints of fatigue were assessed using the Brief Fatigue Inventory (BFI) tool and evaluation of the hormone profiles was done in moderate-to-severe fatigued survivors. Data collected were analyzed to look for any association between fatigue and altered hormonal levels. Results: In this study, 56 per cent (n=62) of survivors experienced moderate-to-severe fatigue out of 110 patients reporting fatigue. Thyroid functions were deranged in 22 patients (35.48%). The thyroid stimulating hormone (TSH) levels were found to have a significant negative association with the severity of fatigue, (P
ISSN:0971-5916
0975-9174
DOI:10.4103/ijmr.IJMR_2989_20