Assessment of Serum Adiponectin and Leptin in Chronic Periodontitis Over Healthy Individuals

ABSTRACT Objective: The objective of the research was to ascertain whether serum levels of the biochemical markers adiponectin and leptin are related to clinical periodontal characteristics. Materials and Method: For the study, 20 people with chronic periodontitis (Group A) and 20 healthy people (Gr...

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Published in:Journal of pharmacy & bioallied science 2024-12, Vol.16 (Suppl 4), p.S3887-S3889
Main Authors: Preethanath, Reghunathan S, Chandy, Swaroop, Syed, Nubesh Khan, Shankar, Bugude Shiva, Seshadri, Pavithra Rangarajan, Narayane, R, Bai, P. K. Saraswathi
Format: Article
Language:English
Subjects:
Adiponectin
Biochemical markers
Enzyme-linked immunosorbent assay
Enzymes
Gingival index
Gum disease
Leptin
Periodontitis
Plaque index
Serum levels
Type 2 diabetes
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Summary:ABSTRACT Objective: The objective of the research was to ascertain whether serum levels of the biochemical markers adiponectin and leptin are related to clinical periodontal characteristics. Materials and Method: For the study, 20 people with chronic periodontitis (Group A) and 20 healthy people (Group B) were enrolled. Assessments were conducted on periodontal markers, including bleeding on probing (POP), gingival index (GI), plaque index (PI), probing pocket depth (PPD), and clinical attachment level (CAL). An enzyme-linked immunosorbent assay (ELISA) test was used to assess the levels of adiponectin and leptin in serum samples. Result: There was significant elevation in average level of leptin in chronic periodontitis in association to that in healthy group. On the other hand, there was considerable decrease in serum adiponectin in group A in association to healthy group. The ratio of leptinadiponectin was appreciably greater amongst periodontitis group compared to healthy group. Conclusion: The current investigation leads us to the conclusion that the pathophysiology of periodontitis is significantly influenced by serum levels of adiponectin and leptin. Keywords: Adiponectin, chronic preiodontitis, leptin, obese individuals, oral health, periodontal diseases, saliva
ISSN:0976-4879
0975-7406
DOI:10.4103/jpbs.jpbs_1355_24