Polymer-coated superparamagnetic iron oxide nanoparticles as T 2 contrast agent for MRI and their uptake in liver

To study the efficiency of multifunctional polymer-based superparamagnetic iron oxide nanoparticles (bioferrofluids) as a T magnetic resonance contrast agent and their uptake and toxicity in liver. Mice were intravenously injected with bioferrofluids and Endorem . The magnetic resonance efficiency,...

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Bibliographic Details
Published in:Future science OA 2019-01, Vol.5 (1), p.FSO235
Main Authors: Ali, Lamiaa Ma, Marzola, Pasquina, Nicolato, Elena, Fiorini, Silvia, Heras Guillamón, Marcelo de Las, Piñol, Rafael, Gabilondo, Lierni, Millán, Angel, Palacio, Fernando
Format: Article
Language:English
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Summary:To study the efficiency of multifunctional polymer-based superparamagnetic iron oxide nanoparticles (bioferrofluids) as a T magnetic resonance contrast agent and their uptake and toxicity in liver. Mice were intravenously injected with bioferrofluids and Endorem . The magnetic resonance efficiency, uptake and toxicity were investigated by means of magnetic resonance imaging (MRI) and histological techniques. Bioferrofluids are a good T contrast agent with a higher r /r ratio than Endorem. Bioferrofluids have a shorter blood circulation time and persist in liver for longer time period compared with Endorem. Both bioferrofluids and Endorem do not generate any noticeable histological lesions in liver over a period of 60 days post-injection. Our bioferrofluids are powerful diagnostic tool without any observed toxicity over a period of 60 days post-injection.
ISSN:2056-5623
2056-5623
DOI:10.4155/fsoa-2017-0054