Evidence of size-dependent effect of silica micro- and nano-particles on basal and specialized monocyte functions

To analyze the effect of silica particles on monocyte/macrophage functions. Silica micro- and nanoparticles were obtained by the Stöber method. Their effect on monocyte/macrophage proliferation, activation, membrane integrity and metabolic activity were determined. Silica particles inhibit cell prol...

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Bibliographic Details
Published in:Therapeutic delivery 2017-12, Vol.8 (12), p.1035-1049
Main Authors: De Marzi, Mauricio C, Saraceno, Martín, Mitarotonda, Romina, Todone, Marcos, Fernandez, Marisa, Malchiodi, Emilio L, Desimone, Martín F
Format: Article
Language:English
Subjects:
activation markers
cell activation
cytokine secretion
monocytes/macrophages
silica nanoparticles
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Summary:To analyze the effect of silica particles on monocyte/macrophage functions. Silica micro- and nanoparticles were obtained by the Stöber method. Their effect on monocyte/macrophage proliferation, activation, membrane integrity and metabolic activity were determined. Silica particles inhibit cell proliferation while 10 nm nanoparticles (NPs) did not affect it. Similarly, silica particles induced strong cell activation. However, 10 nm NPs do not alter IL-12 or nitrite levels. Furthermore, bigger NPs and microparticles increase cell membrane damage and reduce the number of living cells but smallest NPs (10 and 240 nm) did not. Cell activation properties of silica particles could be useful tools for immune stimulation therapy, while 10 nm NPs would be suitable for molecule transportation.
ISSN:2041-5990
2041-6008
DOI:10.4155/tde-2017-0053