Punctum and canalicular anatomy for hydrogel-based intracanalicular insert technology

Despite advances in cataract surgery, postoperative ocular inflammation and pain occurs. To address compliance issues with topical corticosteroid administration, a hydrogel-based dexamethasone insert was developed for intracanalicular administration. The objective is to understand the anatomy to bes...

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Bibliographic Details
Published in:Therapeutic delivery 2020-03, Vol.11 (3), p.173-182
Main Authors: Tyson, Sydney L, Campbell, Patrick, Biggins, James, Driscoll, Arthur, Jarrett, Peter, Gibson, Andrea, Vantipalli, Srilatha, Metzinger, Jamie Lynne, Goldstein, Michael H
Format: Article
Language:English
Subjects:
cataract
dexamethasone
drug delivery
fluorescein
hydrogel
intracanalicular
ocular surface disease
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Summary:Despite advances in cataract surgery, postoperative ocular inflammation and pain occurs. To address compliance issues with topical corticosteroid administration, a hydrogel-based dexamethasone insert was developed for intracanalicular administration. The objective is to understand the anatomy to best administer the insert and learn how the anatomy and hydrogel properties help retain the insert in the canaliculus over time. Human cadavers (n = 5) were dissected to assess dimensions of punctum and canaliculus as part of drug discovery and development. Mean measures for punctal diameter was 0.5 ± 0 mm and vertical canaliculi length was 2.4 ± 0.5 mm and width was 1.6 ± 0.5 mm. Vertical canalicular width was larger than the punctal opening, a critical understanding for placing and retaining intracanalicular inserts.
ISSN:2041-5990
2041-6008
DOI:10.4155/tde-2020-0010