Study of supramolecular complex of nifedipine with arabinogalactan on Wistar and ISIAH rats

Physicochemical and pharmacological study of the supramolecular inclusion complexes of the hypotensive drug nifedipine (NF) with the larch polysaccharide arabinogalactan (AG). The NF:AG complexes were obtained and their physicochemical properties were studied. Their hypotensive action and pharmacoki...

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Bibliographic Details
Published in:Therapeutic delivery 2021-02, Vol.12 (2), p.119-131
Main Authors: Khvostov, Mikhail Vladimirovich, Chernonosov, Alexander Anatolievich, Borisov, Sergey Alkisovich, Borisova, Marina Sergeevna, Meteleva, Elizaveta Sergeevna, Evseenko, Veronika Ivanovna, Polyakov, Nikolay Eduardovich, Dushkin, Alexander Valerievich, Tolstikova, Tatjana Genrihovna
Format: Article
Language:English
Subjects:
arabinogalactan
bioavailability
complexes
drug delivery
mechanochemistry
nifedipine
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Summary:Physicochemical and pharmacological study of the supramolecular inclusion complexes of the hypotensive drug nifedipine (NF) with the larch polysaccharide arabinogalactan (AG). The NF:AG complexes were obtained and their physicochemical properties were studied. Their hypotensive action and pharmacokinetic profiles were evaluated in rats with normal and elevated arterial blood pressure. In both rat lines the NF:AG complex decreased the arterial blood pressure at a lower dose than free NF (1.75 mg/kg of NF in complex compared with 3.5 mg/kg of free NF) and has a better pharmacokinetic profile than free NF. The use of the NF:AG complex is an effective way to sufficiently enhance and hasten NF’s hypotensive action.
ISSN:2041-5990
2041-6008
DOI:10.4155/tde-2020-0115