In situ immunization via non-surgical ablation to prevent local and distant tumor recurrence

Host immunities are induced during cryoablation or oncolytic adenovirus therapy when the entire repertoire of tumor associated antigens (TAA) is released. Local and systemic protection is enhanced by the combined treatment with toll-like receptor agonist or immune stimulating cytokines. Non-surgical...

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Bibliographic Details
Published in:Oncoimmunology 2015-03, Vol.4 (3), p.e989762-e989762
Main Authors: Veenstra, Jesse J, Gibson, Heather M, Freytag, Svend, Littrup, Peter J, Wei, Wei-Zen
Format: Article
Language:English
Subjects:
adenovirus
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CpG
cryoablation
GM-CSF
Her2/neu
IL-12
immunization
mouse mammary tumor
suicide gene
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Summary:Host immunities are induced during cryoablation or oncolytic adenovirus therapy when the entire repertoire of tumor associated antigens (TAA) is released. Local and systemic protection is enhanced by the combined treatment with toll-like receptor agonist or immune stimulating cytokines. Non-surgical tumor ablation is an effective platform for in situ immunization.
ISSN:2162-4011
2162-402X
2162-402X
DOI:10.4161/2162402X.2014.989762