Rapamycin inhibits mTORC1, but not completely

Rapamycin is widely used as a complete inhibitor of the mTORC1 nutrient-sensitive signaling complex. Using a novel ATP-competitive inhibitor named Torin1, we have found that many mTORC1 functions that regulate cap-dependent translation and autophagy are resistant to inhibition by rapamycin.

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Bibliographic Details
Published in:Autophagy 2009-07, Vol.5 (5), p.725-726
Main Authors: Thoreen, Carson C., Sabatini, David M.
Format: Article
Language:English
Subjects:
Animals
Binding
Biology
Bioscience
Calcium
Cancer
Cell
Clinical Trials as Topic
Cycle
Humans
Landes
Mechanistic Target of Rapamycin Complex 1
Mice
Models, Biological
Multiprotein Complexes
Organogenesis
Protein Biosynthesis - drug effects
Proteins
Signal Transduction - drug effects
Sirolimus - pharmacology
TOR Serine-Threonine Kinases
Transcription Factors - antagonists & inhibitors
Transcription Factors - metabolism
Citations: Items that cite this one
Online Access:Get full text
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Description
Summary:Rapamycin is widely used as a complete inhibitor of the mTORC1 nutrient-sensitive signaling complex. Using a novel ATP-competitive inhibitor named Torin1, we have found that many mTORC1 functions that regulate cap-dependent translation and autophagy are resistant to inhibition by rapamycin.
ISSN:1554-8627
1554-8635
DOI:10.4161/auto.5.5.8504