(Citric acid-co-polycaprolactone triol) polyester: A biodegradable elastomer for soft tissue engineering

Tissue engineering holds enormous challenges for materials science, wherein the ideal scaffold to be used is expected to be biocompatible, biodegradable and possess mechanical and physical properties that are suitable for target application. In this context, we have prepared degradable polyesters in...

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Bibliographic Details
Published in:Biomatter (Austin, TX) TX), 2011-07, Vol.1 (1), p.81-90
Main Authors: Thomas, Lynda V., Nair, Prabha D.
Format: Article
Language:English
Subjects:
Absorbable Implants
Animals
Arginine - chemistry
Binding
Biocompatible Materials - chemistry
biodegradable
Biology
Bioscience
Calcium
Calorimetry, Differential Scanning
Cancer
Cell
citric acid
Citric Acid - chemistry
Crystallization
Cycle
elastomeric
Elastomers - chemistry
Fibroblasts - metabolism
Glass
Hemolysis
Human Umbilical Vein Endothelial Cells
Humans
Landes
Materials Testing
Mice
Microscopy, Electron, Scanning
Models, Chemical
Organogenesis
Peptides - chemistry
polycaprolactone triol
polyester
Polyesters - chemistry
Porosity
Proteins
soft tissue engineering
Spectroscopy, Fourier Transform Infrared
Stress, Mechanical
Temperature
Tissue Engineering - instrumentation
Tissue Engineering - methods
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Summary:Tissue engineering holds enormous challenges for materials science, wherein the ideal scaffold to be used is expected to be biocompatible, biodegradable and possess mechanical and physical properties that are suitable for target application. In this context, we have prepared degradable polyesters in different ratios by a simple polycondensation technique with citric acid and polycaprolactone triol. Differential scanning calorimetry indicated that the materials were amorphous based the absence of a crystalline melting peak and the presence of a glass transition temperature below 37°C. These polyesters were found to be hydrophilic and could be tailor-made into tubes and films. Porosity could also be introduced by addition of porogens. All the materials were non-cytotoxic in an in vitro cytotoxicity assay and may degrade via hydrolysis to non-toxic degradation products. These polyesters have potential implications in the field of soft tissue engineering on account of their similarity of properties.
ISSN:2159-2527
2159-2535
2159-2535
DOI:10.4161/biom.1.1.17301