Hsp70-2 is Required for Tumor Cell Growth and Survival

Heat shock protein 70 (Hsp70) family consists of at least eight chaperone proteins that differ from each other by their pattern of expression and intracellular localization. Whereas ample experimental and clinico-pathological data has implicated the major stress-inducible Hsp70-1 as a protein requir...

Full description

Saved in:
Bibliographic Details
Published in:Cell cycle (Georgetown, Tex.) Tex.), 2005-07, Vol.4 (7), p.877-880
Main Authors: Daugaard, Mads, Jäättelä, Marja, Rohde, Mikkel
Format: Article
Language:English
Subjects:
Binding
Biology
Bioscience
Calcium
Cancer
Cell
Cell Growth Processes
Cell Survival
Cycle
HSP70 Heat-Shock Proteins - deficiency
HSP70 Heat-Shock Proteins - genetics
HSP70 Heat-Shock Proteins - metabolism
Humans
Landes
Neoplasms - pathology
Organogenesis
Proteins
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Heat shock protein 70 (Hsp70) family consists of at least eight chaperone proteins that differ from each other by their pattern of expression and intracellular localization. Whereas ample experimental and clinico-pathological data has implicated the major stress-inducible Hsp70-1 as a protein required for cancer cell survival, the study of the other family members has been limited by the lack of experimental tools to differentiate between the highly homologous family members. This limitation has been recently overcome by the RNA interference technology that for the first time allows targeted knockdown of the individual Hsp70 family members. Data based on this technology has revealed that also Hsp70-2, a protein essential for spermatogenesis, is required for cancer cell growth and survival. Remarkably, the highly homologous Hsp70 proteins enhance cancer cell growth and survival by distinct molecular mechanisms.
ISSN:1538-4101
1551-4005
DOI:10.4161/cc.4.7.1838