PI3-K and GSK-3: Akt-ing together with microtubules

Phosphoinositide-3-Kinase (PI3-K) and the downstream kinases Akt and Glycogen Synthase Kinase-3 (GSK-3) have recently been implicated in regulating both microtubule (MT) dynamics and organisation. Here we review the role of this signalling pathway in controlling MTs, and explore ways in which the ki...

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Bibliographic Details
Published in:Cell cycle (Georgetown, Tex.) Tex.), 2008-09, Vol.7 (17), p.2621-2625
Main Authors: Buttrick, Graham J., Wakefield, James G.
Format: Article
Language:English
Subjects:
Animals
Binding
Biology
Bioscience
Calcium
Cancer
Cell
Cell Polarity
Cycle
Glycogen Synthase Kinase 3 - metabolism
Humans
Landes
Microtubules - enzymology
Microtubules - metabolism
Organogenesis
Phosphatidylinositol 3-Kinases - metabolism
Proteins
Proto-Oncogene Proteins c-akt - metabolism
Signal Transduction
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Summary:Phosphoinositide-3-Kinase (PI3-K) and the downstream kinases Akt and Glycogen Synthase Kinase-3 (GSK-3) have recently been implicated in regulating both microtubule (MT) dynamics and organisation. Here we review the role of this signalling pathway in controlling MTs, and explore ways in which the kinases and their substrates may co-operate to spatially regulate MTs in different contexts.
ISSN:1538-4101
1551-4005
DOI:10.4161/cc.7.17.6514