Frequent epigenetic inactivation of RASSF10 in thyroid cancer

The Ras association domain family (RASSF) encodes for distinct tumor suppressors and several members are frequently silenced in human cancer. In our study, we analyzed the role of a novel RASSF member termed RASSF10 in thyroid carcinogenesis. The RASSF10 CpG island promoter was intensively methylate...

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Bibliographic Details
Published in:Epigenetics 2009-11, Vol.4 (8), p.571-576
Main Authors: Schagdarsurengin, Undraga, Richter, Antje M., Wöhler, Christina, Dammann, Reinhard H.
Format: Article
Language:English
Subjects:
Binding
Biology
Bioscience
Calcium
Cancer
Cell
Cell Line, Tumor
CpG Islands
Cycle
DNA Methylation
Epigenesis, Genetic
Gene Expression Regulation, Neoplastic
Gene Silencing
Humans
Landes
Middle Aged
Organogenesis
Proteins
Thyroid Neoplasms - genetics
Thyroid Neoplasms - metabolism
Tumor Suppressor Proteins - genetics
Tumor Suppressor Proteins - metabolism
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Description
Summary:The Ras association domain family (RASSF) encodes for distinct tumor suppressors and several members are frequently silenced in human cancer. In our study, we analyzed the role of a novel RASSF member termed RASSF10 in thyroid carcinogenesis. The RASSF10 CpG island promoter was intensively methylated in nine thyroid cancer cell lines and in 66% of primary thyroid carcinomas. RASSF10 methylation was significantly increased in primary thyroid carcinoma compared to normal thyroid and follicular adenoma (0% and 10%, respectively; p
ISSN:1559-2294
1559-2308
DOI:10.4161/epi.4.8.10056