Plant-derived vaccines: An approach for affordable vaccines against cervical cancer

Several types of human papillomavirus (HPV) are causatively associated with cervical cancer, which is the second most common cancer in women worldwide. HPV-16 and 18 are among the high risk types and responsible for HPV infection in more than 70% of the cases. The majority of cervical cancer cases o...

Full description

Saved in:
Bibliographic Details
Published in:Human vaccines & immunotherapeutics 2012-03, Vol.8 (3), p.403-406
Main Authors: Waheed, Mohammad Tahir, Gottschamel, Johanna, Hassan, Syed Waqas, Lössl, Andreas Günter
Format: Article
Language:English
Subjects:
adjuvant
Binding
Biology
biosafety
Bioscience
Biotechnology - methods
Calcium
Cancer
Cell
chloroplast transformation
cost-effective vaccines
Cycle
Female
human papillomavirus
Humans
Landes
LTB
Organogenesis
Papillomavirus Infections - complications
Papillomavirus Infections - prevention & control
Papillomavirus Vaccines - immunology
Papillomavirus Vaccines - isolation & purification
plant-derived vaccines
Plants, Genetically Modified
Proteins
Technology, Pharmaceutical - methods
Uterine Cervical Neoplasms - prevention & control
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Several types of human papillomavirus (HPV) are causatively associated with cervical cancer, which is the second most common cancer in women worldwide. HPV-16 and 18 are among the high risk types and responsible for HPV infection in more than 70% of the cases. The majority of cervical cancer cases occur in developing countries. Currently available HPV vaccines are expensive and probably unaffordable for most women in low and middle income countries. Therefore, there is a need to develop cost-effective vaccines for these countries. Due to many advantages, plants offer an attractive platform for the development of affordable vaccines. These include low cost of production, scalability, low health risks and the potential ability to be used as unprocessed or partially processed material. Among several techniques, chloroplast transformation is of eminent interest for the production of vaccines because of high yield of foreign protein and lack of transgene transmission through pollen. In this commentary, we focus on the most relevant aspects of plant-derived vaccines that are decisive for the future development of cost-effective HPV vaccines.
ISSN:2164-5515
2164-554X
DOI:10.4161/hv.18568