Mucosal vaccines: Novel strategies and applications for the control of pathogens and tumors at mucosal sites

The mucosal immune system displays several adaptations reflecting the exposure to the external environment. The efficient induction of mucosal immune responses also requires specific approaches, such as the use of appropriate administration routes and specific adjuvants and/or delivery systems. In c...

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Bibliographic Details
Published in:Human vaccines & immunotherapeutics 2014-08, Vol.10 (8), p.2175-2187
Main Authors: Nizard, Mevyn, Diniz, Mariana O, Roussel, Helene, Tran, Thi, Ferreira, Luis CS, Badoual, Cecile, Tartour, Eric
Format: Article
Language:English
Subjects:
Administration, Mucosal
Animals
cancer vaccines
homing molecules
Humans
Immunity, Mucosal
immunization routes
mucosal adjuvants
mucosal imprinting
mucosal vaccines
resident memory T cells
Review
Vaccines - administration & dosage
Vaccines - immunology
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Summary:The mucosal immune system displays several adaptations reflecting the exposure to the external environment. The efficient induction of mucosal immune responses also requires specific approaches, such as the use of appropriate administration routes and specific adjuvants and/or delivery systems. In contrast to vaccines delivered via parenteral routes, experimental, and clinical evidences demonstrated that mucosal vaccines can efficiently induce local immune responses to pathogens or tumors located at mucosal sites as well as systemic response. At least in part, such features can be explained by the compartmentalization of mucosal B and T cell populations that play important roles in the modulation of local immune responses. In the present review, we discuss molecular and cellular features of the mucosal immune system as well as novel immunization approaches that may lead to the development of innovative and efficient vaccines targeting pathogens and tumors at different mucosal sites.
ISSN:2164-5515
2164-554X
DOI:10.4161/hv.29269