Wheezing and itching: The requirement for STAT proteins in allergic inflammation

The development of allergic inflammation requires the orchestration of gene expression from the inflamed tissue and from the infiltrating immune cells. Since many of the cytokines that promote allergic inflammation signal through hematopoietin family receptors, the Signal Transducer and Activator of...

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Bibliographic Details
Published in:JAK-STAT 2012-01, Vol.1 (1), p.3-15
Main Authors: Glosson, Nicole L., Bruns, Heather A., Kaplan, Mark H.
Format: Article
Language:English
Subjects:
allergy
atopy
Binding
Biology
Bioscience
Calcium
Cancer
Cell
Cycle
inflammation
Landes
mouse model
Organogenesis
Proteins
Review
transcription factor
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Summary:The development of allergic inflammation requires the orchestration of gene expression from the inflamed tissue and from the infiltrating immune cells. Since many of the cytokines that promote allergic inflammation signal through hematopoietin family receptors, the Signal Transducer and Activator of Transcription (STAT) family have obligate roles in pro-allergic cytokine-induced gene regulation in multiple cell types. In this review, we summarize work defining the contribution of each of the STAT family members to the development of allergic inflammation, using data from mouse models of allergic inflammation, studies on patient samples and correlations with single nucleotide polymorphisms in STAT genes.
ISSN:2162-3988
2162-3996
2162-3996
DOI:10.4161/jkst.19086