The role of mRNA structure in translational control in bacteria

During the past few years, our knowledge on RNA-based regulation in many organisms has tremendously increased. In bacteria, although transcriptional regulatory proteins remain key players in gene regulation, a wide variety of post-transcriptional regulatory mechanisms discovered highlights the impor...

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Bibliographic Details
Published in:RNA biology 2009-04, Vol.6 (2), p.153-160
Main Authors: Geissmann, Thomas, Marzi, Stefano, Romby, Pascale
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Bacteria - genetics
Bacterial Proteins - chemistry
Bacterial Proteins - genetics
Binding
Biology
Bioscience
Calcium
Cancer
Cell
Cycle
Landes
Molecular Sequence Data
Nucleic Acid Conformation
Organogenesis
Protein Biosynthesis
Proteins
RNA, Messenger - chemistry
Sequence Homology, Amino Acid
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Summary:During the past few years, our knowledge on RNA-based regulation in many organisms has tremendously increased. In bacteria, although transcriptional regulatory proteins remain key players in gene regulation, a wide variety of post-transcriptional regulatory mechanisms discovered highlights the importance of the mRNA structure in the regulation of gene expression. RNA-dependent regulation largely contributes to rapidly adapt the bacterial metabolism in response to environmental changes, stress and in establishment of virulence. Bacteria exploit the extraordinary ability of mRNA to fold into different structures in response to various signals (environmental cues, ligand binding). Induced mRNA conformational rearrangements can potentially regulate transcription, translation and mRNA stability. The present review focuses on the structures of regulatory regions of mRNA that have evolved to permit productive interactions with trans-acting regulators, such as protein or non-coding RNAs. Finally, we describe how particular properties of these regulatory complexes regulate translation initiation.
ISSN:1547-6286
1555-8584
DOI:10.4161/rna.6.2.8047