Endocrine resistance in breast cancer: From cellular signaling pathways to epigenetic mechanisms

Although multiple cellular mechanisms have been proposed to explain endocrine resistance in breast cancer, the genomics events promoting the dysregulation of gene expression pattern are not clearly understood. Because chromatin plays a dynamic role in the estrogen receptor α (ERα) transcriptional pr...

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Bibliographic Details
Published in:Transcription 2012-07, Vol.3 (4), p.165-170
Main Authors: Bianco, Stéphanie, Gévry, Nicolas
Format: Article
Language:English
Subjects:
Antineoplastic Agents, Hormonal - pharmacology
Antineoplastic Agents, Hormonal - therapeutic use
Binding
Biology
Bioscience
breast cancer
Breast Neoplasms - drug therapy
Breast Neoplasms - genetics
Breast Neoplasms - metabolism
Calcium
Cancer
Cell
chromatin
Chromatin - genetics
Chromatin - metabolism
Cycle
Drug Resistance, Neoplasm - genetics
endocrine resistance
Epigenesis, Genetic
epigenetic
Female
Gene Expression Regulation, Neoplastic
genomic
Humans
Landes
Organogenesis
Point of View
Proteins
Receptors, Estrogen - genetics
Receptors, Estrogen - metabolism
Signal Transduction
Tamoxifen - pharmacology
Tamoxifen - therapeutic use
transcription factor
Transcription, Genetic
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Description
Summary:Although multiple cellular mechanisms have been proposed to explain endocrine resistance in breast cancer, the genomics events promoting the dysregulation of gene expression pattern are not clearly understood. Because chromatin plays a dynamic role in the estrogen receptor α (ERα) transcriptional program, we herein review signaling pathways implicated in endocrine resistance and try to merge them with recent epigenetic studies.
ISSN:2154-1264
2154-1272
DOI:10.4161/trns.20496