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Effect of Aqueous Allium Cepa Extract from Red Onion on Aluminum Chloride-Induced Anemia in Female Rats
This study examined the protective effect of Allium cepa extract from red onion on aluminum - induced anemia in female wistar rats. Twenty-four animals (six rats per group) were used for this study. They were divided into four groups: group one served as control, group two animals were treated with...
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Published in: | Journal of Applied Sciences and Environmental Management 2018-12, Vol.21 (7), p.1286 |
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Main Authors: | , |
Format: | Article |
Language: | English |
Subjects: | |
Online Access: | Get full text |
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Summary: | This study examined the protective effect of Allium cepa extract from
red onion on aluminum - induced anemia in female wistar rats.
Twenty-four animals (six rats per group) were used for this study. They
were divided into four groups: group one served as control, group two
animals were treated with 100mg/kg BW of aluminum chloride and served
as Aluminum chloride (AlCl3) group, group three, Allium cepa alone
group were treated with 1mL/100g BW of Allium cepa while group four was
simultaneously treated with 1mL/100g BW of Allium cepa and 100mg/kg BW
AlCl3. Treatments lasted for 4 weeks. Red blood cells (RBC), packed
cell volume (PCV), Hemoglobin concentration (Hb) were measured from
blood sample collected from each rat. Serum urea, serum and kidney
malondialdehyde (index of lipid peroxidation) and kidney catalase and
superoxide dismutase (SOD) activities were measured
spectrophotometrically. Significant decrease in RBC, PCV, Hb, catalase,
SOD and significant increase in serum urea and malondialdehyde were
observed in aluminum treated animals when compared with control.
Animals treated with Allium cepa alone had significant increase in PCV,
Hb, SOD and significant decrease in malondialdehyde and serum urea
while there was no significant different in RBC and catalase when
compared with control. Simultaneous treatment of the animals with
Allium cepa and aluminum chloride resulted in significant increase in
PCV while there was no significant different in RBC, Hb, catalase,
malondialdehyde when compared with control.This study reveals that
Allium cepa extract treatment ameliorate aluminum-induced anemia
through antioxidant system. |
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ISSN: | 1119-8362 2659-1502 2659-1499 |
DOI: | 10.4314/jasem.v21i7.11 |