Protective Effects of Trans-Ferulic acid on Tamoxifen Induced Heptatic and Renal Oxidative Stress in Male Wister Albino Rat

• Published in: Journal of Applied Sciences and Environmental Management 2023-09, Vol.27 (8), p.1727-1732
• Main Authors: Ogbuta, A. A., Given, O. T., Ebinistei, P., Alexis, E. O., Wellington, E. O., Teke, E. C., Manda, A. E.
• Format: Article
• Language: English
• Subjects: Hepatic; Oxidative stress; Renal; Tamoxifen; Trans-Ferullic acid
• ISSN: 1119-8362; 2659-1502; 2659-1502; 2659-1499
• DOI: 10.4314/jasem.v27i8.16

This study was designed to assess the protective effects of trans-ferulic acid on tamoxifen induced hepatic and renal oxidative stress in male Wister albino rates using appropriate standard methods. Twenty four male albino rats were randomly divided into 4 (four) groups of 6 (six) animals each. Group A, B, C and D where group A is control animals group B and C animals were treated with 0.4 mg/kgof tamoxifen and100 mg/kg body weight of trans-ferulic acid respectively. Group D animals were simultaneously administered with 100 mg/kg of trans-ferulic acid and 0.4 mg/kg of tamoxifen for twenty one days. UV/VIS spectrophotometer was used for the analysis of indicators. A significant elevation was observed in plasma bilirubin, urea and creatinine by tamoxifen treated group with mean concentrations of 35.50 ± 1.8 mg/dl, 2.15±0.06 mg/dl and 7.80 ±9.29 mg/dl respectively, when observed with mean concentrations of control group 14.7±0.31 mg/dl, 0.98±0.05 mg/dl and 3.31±0.15 mg/dl. While the mean concentrations of trans-ferulicacid treatment were 21.2±0.36 mg/dl,1.07±0.03 and 3.65 mg/dl, significantly protected on the effects of the tamoxifen- induced. ALP, AST, ALT activities were also increased significantly (p