Protective Effects of Trans-Ferulic acid on Tamoxifen Induced Heptatic and Renal Oxidative Stress in Male Wister Albino Rat

This study was designed to assess the protective effects of trans-ferulic acid on tamoxifen induced hepatic and renal oxidative stress in male Wister albino rates using appropriate standard methods. Twenty four male albino rats were randomly divided into 4 (four) groups of 6 (six) animals each. Grou...

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Published in:Journal of Applied Sciences and Environmental Management 2023-09, Vol.27 (8), p.1727-1732
Main Authors: Ogbuta, A. A., Given, O. T., Ebinistei, P., Alexis, E. O., Wellington, E. O., Teke, E. C., Manda, A. E.
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Hepatic
Oxidative stress
Renal
Tamoxifen
Trans-Ferullic acid
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container_title Journal of Applied Sciences and Environmental Management
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creator Ogbuta, A. A.
Given, O. T.
Ebinistei, P.
Alexis, E. O.
Wellington, E. O.
Teke, E. C.
Manda, A. E.
description This study was designed to assess the protective effects of trans-ferulic acid on tamoxifen induced hepatic and renal oxidative stress in male Wister albino rates using appropriate standard methods. Twenty four male albino rats were randomly divided into 4 (four) groups of 6 (six) animals each. Group A, B, C and D where group A is control animals group B and C animals were treated with 0.4 mg/kgof tamoxifen and100 mg/kg body weight of trans-ferulic acid respectively. Group D animals were simultaneously administered with 100 mg/kg of trans-ferulic acid and 0.4 mg/kg of tamoxifen for twenty one days. UV/VIS spectrophotometer was used for the analysis of indicators. A significant elevation was observed in plasma bilirubin, urea and creatinine by tamoxifen treated group with mean concentrations of 35.50 ± 1.8 mg/dl, 2.15±0.06 mg/dl and 7.80 ±9.29 mg/dl respectively, when observed with mean concentrations of control group 14.7±0.31 mg/dl, 0.98±0.05 mg/dl and 3.31±0.15 mg/dl. While the mean concentrations of trans-ferulicacid treatment were 21.2±0.36 mg/dl,1.07±0.03 and 3.65 mg/dl, significantly protected on the effects of the tamoxifen- induced. ALP, AST, ALT activities were also increased significantly (p
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A. ; Given, O. T. ; Ebinistei, P. ; Alexis, E. O. ; Wellington, E. O. ; Teke, E. C. ; Manda, A. E.</creator><creatorcontrib>Ogbuta, A. A. ; Given, O. T. ; Ebinistei, P. ; Alexis, E. O. ; Wellington, E. O. ; Teke, E. C. ; Manda, A. E.</creatorcontrib><description>This study was designed to assess the protective effects of trans-ferulic acid on tamoxifen induced hepatic and renal oxidative stress in male Wister albino rates using appropriate standard methods. Twenty four male albino rats were randomly divided into 4 (four) groups of 6 (six) animals each. Group A, B, C and D where group A is control animals group B and C animals were treated with 0.4 mg/kgof tamoxifen and100 mg/kg body weight of trans-ferulic acid respectively. Group D animals were simultaneously administered with 100 mg/kg of trans-ferulic acid and 0.4 mg/kg of tamoxifen for twenty one days. UV/VIS spectrophotometer was used for the analysis of indicators. A significant elevation was observed in plasma bilirubin, urea and creatinine by tamoxifen treated group with mean concentrations of 35.50 ± 1.8 mg/dl, 2.15±0.06 mg/dl and 7.80 ±9.29 mg/dl respectively, when observed with mean concentrations of control group 14.7±0.31 mg/dl, 0.98±0.05 mg/dl and 3.31±0.15 mg/dl. While the mean concentrations of trans-ferulicacid treatment were 21.2±0.36 mg/dl,1.07±0.03 and 3.65 mg/dl, significantly protected on the effects of the tamoxifen- induced. ALP, AST, ALT activities were also increased significantly (p&lt;0.05) on mean concentration of 65±1.0 U/L, 11.08±0.12 U/L and 678.20±13.30 U/L in the treated group by tamoxifen respectively when viewed with the control (p&lt;0.05) and trans-ferulic acid treatment reduced the increased enzyme activities by mean concentrations of 43.6±1.0, 5.54±0.26 U/L and. Furthermore, tamoxifen administration decreased the level of hepatic superoxide dismutase (SOD), and catalase (CAT) activities by 32.5±2.30 µmole and 0.50±0.05µmole respectively when viewed with mean concentration of the control (49.0±1.15µmole and 1.37±0.02µmole) and trans-ferulic acid treatments significantly ameliorated the decreased in the hepatic enzymes activities (P&lt;0.05) with mean valued 44.0±1.40 and 1.26 ± 0.05 µmole. Also the level of hepatic ascorbic acid was decreased significantly on treatment with tamoxifen by 41.7±2.9 U/L when compared with the mean concentration of the control (60.48±1.45 U/L), while treatment with trans-ferulic acid protected against the decreased level of ascorbic acid by 55.44±1.76 U/L. 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ALP, AST, ALT activities were also increased significantly (p&lt;0.05) on mean concentration of 65±1.0 U/L, 11.08±0.12 U/L and 678.20±13.30 U/L in the treated group by tamoxifen respectively when viewed with the control (p&lt;0.05) and trans-ferulic acid treatment reduced the increased enzyme activities by mean concentrations of 43.6±1.0, 5.54±0.26 U/L and. Furthermore, tamoxifen administration decreased the level of hepatic superoxide dismutase (SOD), and catalase (CAT) activities by 32.5±2.30 µmole and 0.50±0.05µmole respectively when viewed with mean concentration of the control (49.0±1.15µmole and 1.37±0.02µmole) and trans-ferulic acid treatments significantly ameliorated the decreased in the hepatic enzymes activities (P&lt;0.05) with mean valued 44.0±1.40 and 1.26 ± 0.05 µmole. 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subjects Hepatic
Oxidative stress
Renal
Tamoxifen
Trans-Ferullic acid
title Protective Effects of Trans-Ferulic acid on Tamoxifen Induced Heptatic and Renal Oxidative Stress in Male Wister Albino Rat
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