Biological synthesis of silver nanoparticles using Citrus sinesis seeds: Effects on hepatic and renal functional integrities and antioxidant activities

• Published in: Research journal of health sciences 2022-05, Vol.10 (2), p.66-79
• Main Authors: Fatoki, J.O., Badmus, J.A., Ajilore, B.S., Faokunla, O., Alabi, S.O.
• Format: Article
• Language: English
• ISSN: 2360-7793; 2467-8252
• DOI: 10.4314/rejhs.v10i2.1

Objective: This work reports the possible toxicological effects of AgNPs on the liver and kidney. Additionally, it also beamed its searchlight on its effects on the antioxidant defense mechanism in male Wistar rats.Method: Male Wistar rats (n=28) were used for the study. Control animals (n=7) were exposed to only drinking ware ad-libitum for 12 weeks. The remaining 21 rats were randomized into 3 groups of 7 animals each and were exposed to 50, 150 and 250 kg/mg body weight AgNPs biosynthesized from Citrus sinensisi for the same period after which blood and liver were removed from the rats and analyzed spectrophotometrically.Results: A non-significant reduction of plasma ALT, AST, ?GT and ALP characterized the effects of AgNPs in the animal tested. Similarly, AgNPs significantly depleted the plasma creatinine and urea level. The exposure also up-regulated the activities/concentration of antioxidant markers. Malondialdehyde concentration was also significantly depleted by AgNPs.Conclusion: The findings from this study revealed that biologically synthesized AgNPs induced no toxicological potential on hepatic and renal structural and functional integrity. Meanwhile, it enhanced the activities and concentration of antioxidant markers.