Morphoanatomy of striated myofibers in streptozotocin-induced diabetic wistar rats: assuaging effect of combined doses of Vernonia amygdalina and Azadirachta indica

Objective: This study aimed to evaluate the effects of Azadirachta indica and Vernonia amygdalina extracts on the morphoanatomy of striated  myofibrils in diabetic rat models. Methodology: Thirty Wistar rats randomly assigned into 5 groups of 6 rats/group were used. Group A received distilled water...

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Published in:Research journal of health sciences 2020-07, Vol.8 (2), p.92-101
Main Authors: Yama, O.E., Adeteye, O.V., Kusemiju, T.O., Avidime, O.M., Danboyi, T., Odetola, A.A., Mohammed, K.A.
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container_issue 2
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container_title Research journal of health sciences
container_volume 8
creator Yama, O.E.
Adeteye, O.V.
Kusemiju, T.O.
Avidime, O.M.
Danboyi, T.
Odetola, A.A.
Mohammed, K.A.
description Objective: This study aimed to evaluate the effects of Azadirachta indica and Vernonia amygdalina extracts on the morphoanatomy of striated  myofibrils in diabetic rat models. Methodology: Thirty Wistar rats randomly assigned into 5 groups of 6 rats/group were used. Group A received distilled water only, B (herbal) received A. indica (500 mg/kg/day) and V. amygdalina (400 mg/kg/day) simultaneously, C were diabetic rats, D were diabetic rats treated with  herbal extracts combined and E, diabetic rats treated with metformin. Diabetes was induced with streptozotocin (70 mg/kg). Muscles glutathione peroxidase (GPx) and blood glucose levels were determined. The rats were sacrificed at the end of 60days treatment. The quadriceps femoris  muscle harvested for histology. Results: Diabetic herbal treated rats became euglycemic by the end of 8 weeks. GPx activity was significantly (p
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Methodology: Thirty Wistar rats randomly assigned into 5 groups of 6 rats/group were used. Group A received distilled water only, B (herbal) received A. indica (500 mg/kg/day) and V. amygdalina (400 mg/kg/day) simultaneously, C were diabetic rats, D were diabetic rats treated with  herbal extracts combined and E, diabetic rats treated with metformin. Diabetes was induced with streptozotocin (70 mg/kg). Muscles glutathione peroxidase (GPx) and blood glucose levels were determined. The rats were sacrificed at the end of 60days treatment. The quadriceps femoris  muscle harvested for histology. Results: Diabetic herbal treated rats became euglycemic by the end of 8 weeks. GPx activity was significantly (p&lt;0.05) elevated compared to control.  The histology of skeletal muscle fibers of the diabetic rats treated with herbal formulation and metformin showed minimal level of damage.Conclusions: The findings in this study showed that the herbal formulation could be used in treatment of diabetes and in ameliorating the  associated muscular cytoarchitectural alterations. 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Methodology: Thirty Wistar rats randomly assigned into 5 groups of 6 rats/group were used. Group A received distilled water only, B (herbal) received A. indica (500 mg/kg/day) and V. amygdalina (400 mg/kg/day) simultaneously, C were diabetic rats, D were diabetic rats treated with  herbal extracts combined and E, diabetic rats treated with metformin. Diabetes was induced with streptozotocin (70 mg/kg). Muscles glutathione peroxidase (GPx) and blood glucose levels were determined. The rats were sacrificed at the end of 60days treatment. The quadriceps femoris  muscle harvested for histology. Results: Diabetic herbal treated rats became euglycemic by the end of 8 weeks. GPx activity was significantly (p&lt;0.05) elevated compared to control.  The histology of skeletal muscle fibers of the diabetic rats treated with herbal formulation and metformin showed minimal level of damage.Conclusions: The findings in this study showed that the herbal formulation could be used in treatment of diabetes and in ameliorating the  associated muscular cytoarchitectural alterations. 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title Morphoanatomy of striated myofibers in streptozotocin-induced diabetic wistar rats: assuaging effect of combined doses of Vernonia amygdalina and Azadirachta indica
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