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Production of Methioninase from Serratia Marcescens Isolated from Soil and its Anti-Cancer Activity against Dalton's Lymphoma Ascitic (DLA) and Ehrlich Ascitic Carcinoma (EAC) in Swiss Albino Mice
Purpose: To evaluate the anticancer activity of an enzyme, methioninase, obtained from a soil isolate, Serratia marcescens , against Dalton's lymphoma ascitic (DLA) and Ehrlich ascitic carcinoma (EAC) in Swiss albino mice. Methods: Cancer was induced using DLA and EAC cells in Swiss albino mice...
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| Published in: | Tropical journal of pharmaceutical research 2013-10, Vol.12 (5) |
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| Language: | English |
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| container_issue | 5 |
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| container_title | Tropical journal of pharmaceutical research |
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| creator | Sundar, William Arputha Nellaiah, Hariharan |
| description | Purpose: To evaluate the anticancer activity of an enzyme,
methioninase, obtained from a soil isolate, Serratia marcescens ,
against Dalton's lymphoma ascitic (DLA) and Ehrlich ascitic
carcinoma (EAC) in Swiss albino mice. Methods: Cancer was induced using
DLA and EAC cells in Swiss albino mice by intraperitoneal injection.
The mice were then treated with 10 and 20 mg/kg body weight of
methioninase; 5-fluorouracil (5-FU) was used as standard. Results: The
results showed good improvement in haematological parameters,
improvement serum enzymes and lipid profile, as well as increase in
life span by up to 77 %, increase in body weight (p < 0.01),
decrease in cancer cell count from (2.70 ± 0.40) × 106 to
(1.86 ± 0.30) × 106 cells/ml compared to (2.70 ± 0.40)
× 106 to (1.42 ± 0.25) x 106 cells/ml for the group treated
with 5-FU. Solid tumor volume decreased from 5.82 ± 0.15 to 4.10
± 0.11 ml as as against a decrease from 5.82 ± 0.40 to 3.56
± 0.28 for the group treated with 5-FU. Conclusion: The isolated
enzyme, methioninase, has a good anti-cancer activity and needs to be
further be investigated for this activity. |
| doi_str_mv | 10.4314/tjpr.v12i5.6 |
| format | article |
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methioninase, obtained from a soil isolate, Serratia marcescens ,
against Dalton's lymphoma ascitic (DLA) and Ehrlich ascitic
carcinoma (EAC) in Swiss albino mice. Methods: Cancer was induced using
DLA and EAC cells in Swiss albino mice by intraperitoneal injection.
The mice were then treated with 10 and 20 mg/kg body weight of
methioninase; 5-fluorouracil (5-FU) was used as standard. Results: The
results showed good improvement in haematological parameters,
improvement serum enzymes and lipid profile, as well as increase in
life span by up to 77 %, increase in body weight (p < 0.01),
decrease in cancer cell count from (2.70 ± 0.40) × 106 to
(1.86 ± 0.30) × 106 cells/ml compared to (2.70 ± 0.40)
× 106 to (1.42 ± 0.25) x 106 cells/ml for the group treated
with 5-FU. Solid tumor volume decreased from 5.82 ± 0.15 to 4.10
± 0.11 ml as as against a decrease from 5.82 ± 0.40 to 3.56
± 0.28 for the group treated with 5-FU. Conclusion: The isolated
enzyme, methioninase, has a good anti-cancer activity and needs to be
further be investigated for this activity.</description><identifier>ISSN: 1596-5996</identifier><identifier>EISSN: 1596-9827</identifier><identifier>DOI: 10.4314/tjpr.v12i5.6</identifier><language>eng</language><publisher>Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria</publisher><subject>Anticancer ; Dalton's lymphoma ascetic ; Ehrlich ascitic carcinoma ; Methioninase ; Serum depletion ; Tumor</subject><ispartof>Tropical journal of pharmaceutical research, 2013-10, Vol.12 (5)</ispartof><rights>Copyright 2013 - Tropical Journal of Pharmaceutical Research</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b274t-aebf33ffe97b2ca52a076049075f3d9e614cccac629bbd71998af3fadedd60f13</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,860,27903,27904</link.rule.ids></links><search><creatorcontrib>Sundar, William Arputha</creatorcontrib><creatorcontrib>Nellaiah, Hariharan</creatorcontrib><title>Production of Methioninase from Serratia Marcescens Isolated from Soil and its Anti-Cancer Activity against Dalton's Lymphoma Ascitic (DLA) and Ehrlich Ascitic Carcinoma (EAC) in Swiss Albino Mice</title><title>Tropical journal of pharmaceutical research</title><description>Purpose: To evaluate the anticancer activity of an enzyme,
methioninase, obtained from a soil isolate, Serratia marcescens ,
against Dalton's lymphoma ascitic (DLA) and Ehrlich ascitic
carcinoma (EAC) in Swiss albino mice. Methods: Cancer was induced using
DLA and EAC cells in Swiss albino mice by intraperitoneal injection.
The mice were then treated with 10 and 20 mg/kg body weight of
methioninase; 5-fluorouracil (5-FU) was used as standard. Results: The
results showed good improvement in haematological parameters,
improvement serum enzymes and lipid profile, as well as increase in
life span by up to 77 %, increase in body weight (p < 0.01),
decrease in cancer cell count from (2.70 ± 0.40) × 106 to
(1.86 ± 0.30) × 106 cells/ml compared to (2.70 ± 0.40)
× 106 to (1.42 ± 0.25) x 106 cells/ml for the group treated
with 5-FU. Solid tumor volume decreased from 5.82 ± 0.15 to 4.10
± 0.11 ml as as against a decrease from 5.82 ± 0.40 to 3.56
± 0.28 for the group treated with 5-FU. Conclusion: The isolated
enzyme, methioninase, has a good anti-cancer activity and needs to be
further be investigated for this activity.</description><subject>Anticancer</subject><subject>Dalton's lymphoma ascetic</subject><subject>Ehrlich ascitic carcinoma</subject><subject>Methioninase</subject><subject>Serum depletion</subject><subject>Tumor</subject><issn>1596-5996</issn><issn>1596-9827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNpFkc1KLDEQhRtR8HfnA9ROBXtu0j_pybJpx3uFGRTUdVOdTpySnmRIojLv54PZo4MXCqo49XHO4iTJOWeTIufFn_i69pN3nlE5EXvJES-lSOU0q_Z3dymlOEyOQ3hlrBRS8qPk88G7_k1FchacgYWOy_Eki0GD8W4Fj9p7jISwQK90UNoGuAtuwKj7HeFoALQ9UAxQ20hpg1ZpD_Vo-05xA_iCZEOEGxyisxcB5pvVeulWCHVQFEnB5c28vvo2mS39QGr5-2nGWLJb9nJWN1dAFh4_KIxJQzfqsCClT5MDg0PQZ7t9kjzfzp6af-n8_u9dU8_TLquKmKLuTJ4bo2XVZQrLDFklWCFZVZq8l1rwQimFSmSy6_qKSzlFkxvsdd8LZnh-klz_-CrvQvDatGtPK_SblrN220C7baD9bqAVIz75wTtyA1n9SytP2P4Xx-E5m5b5F9hrj7U</recordid><startdate>20131001</startdate><enddate>20131001</enddate><creator>Sundar, William Arputha</creator><creator>Nellaiah, Hariharan</creator><general>Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria</general><scope>RBI</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20131001</creationdate><title>Production of Methioninase from Serratia Marcescens Isolated from Soil and its Anti-Cancer Activity against Dalton's Lymphoma Ascitic (DLA) and Ehrlich Ascitic Carcinoma (EAC) in Swiss Albino Mice</title><author>Sundar, William Arputha ; Nellaiah, Hariharan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b274t-aebf33ffe97b2ca52a076049075f3d9e614cccac629bbd71998af3fadedd60f13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Anticancer</topic><topic>Dalton's lymphoma ascetic</topic><topic>Ehrlich ascitic carcinoma</topic><topic>Methioninase</topic><topic>Serum depletion</topic><topic>Tumor</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sundar, William Arputha</creatorcontrib><creatorcontrib>Nellaiah, Hariharan</creatorcontrib><collection>Bioline International</collection><collection>CrossRef</collection><jtitle>Tropical journal of pharmaceutical research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sundar, William Arputha</au><au>Nellaiah, Hariharan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Production of Methioninase from Serratia Marcescens Isolated from Soil and its Anti-Cancer Activity against Dalton's Lymphoma Ascitic (DLA) and Ehrlich Ascitic Carcinoma (EAC) in Swiss Albino Mice</atitle><jtitle>Tropical journal of pharmaceutical research</jtitle><date>2013-10-01</date><risdate>2013</risdate><volume>12</volume><issue>5</issue><issn>1596-5996</issn><eissn>1596-9827</eissn><abstract>Purpose: To evaluate the anticancer activity of an enzyme,
methioninase, obtained from a soil isolate, Serratia marcescens ,
against Dalton's lymphoma ascitic (DLA) and Ehrlich ascitic
carcinoma (EAC) in Swiss albino mice. Methods: Cancer was induced using
DLA and EAC cells in Swiss albino mice by intraperitoneal injection.
The mice were then treated with 10 and 20 mg/kg body weight of
methioninase; 5-fluorouracil (5-FU) was used as standard. Results: The
results showed good improvement in haematological parameters,
improvement serum enzymes and lipid profile, as well as increase in
life span by up to 77 %, increase in body weight (p < 0.01),
decrease in cancer cell count from (2.70 ± 0.40) × 106 to
(1.86 ± 0.30) × 106 cells/ml compared to (2.70 ± 0.40)
× 106 to (1.42 ± 0.25) x 106 cells/ml for the group treated
with 5-FU. Solid tumor volume decreased from 5.82 ± 0.15 to 4.10
± 0.11 ml as as against a decrease from 5.82 ± 0.40 to 3.56
± 0.28 for the group treated with 5-FU. Conclusion: The isolated
enzyme, methioninase, has a good anti-cancer activity and needs to be
further be investigated for this activity.</abstract><pub>Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria</pub><doi>10.4314/tjpr.v12i5.6</doi><oa>free_for_read</oa></addata></record> |
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| ispartof | Tropical journal of pharmaceutical research, 2013-10, Vol.12 (5) |
| issn | 1596-5996 1596-9827 |
| language | eng |
| recordid | cdi_crossref_primary_10_4314_tjpr_v12i5_6 |
| source | DOAJ Directory of Open Access Journals |
| subjects | Anticancer Dalton's lymphoma ascetic Ehrlich ascitic carcinoma Methioninase Serum depletion Tumor |
| title | Production of Methioninase from Serratia Marcescens Isolated from Soil and its Anti-Cancer Activity against Dalton's Lymphoma Ascitic (DLA) and Ehrlich Ascitic Carcinoma (EAC) in Swiss Albino Mice |
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