Coordination Compounds of M(II) Biometal Ions with Acid - Type Anti - inflammatory Drugs as Ligands - A Review

• Published in: Tropical journal of pharmaceutical research 2015-06, Vol.14 (2), p.337
• Main Authors: Krstic, NS, Nikolic, RS, Stankovic, MN, Nikolic, NG, Dordevic, DM
• Format: Article
• Language: English
• Subjects: Anti - inflammatory medicin; Biometals M(II); Cobalt; Coordination; Copper; Manganese; O - Donor ligands; Zinc
• ISSN: 1596-5996; 1596-9827
• DOI: 10.4314/tjpr.v14i2.21

The cations of biometals in biological systems easily interact with various moieties of organic and inorganic biomolecules, either as natural constituents or after introduction into the body via O - , N - and S - donor atoms. Study of the interaction between M(II) biometal - O - donor ligand (drug) is of interest for various reasons: more evenly dosing of medicine and biodistribution of medicine; monitoring of its pharmacokinetics including excretion; reduction of unwanted effects of the medicine; greater antimicrobial activity; synergistic effect of the metal and medicine; and improved anti - ulcer ous, anti - tumor and anti - bacterial activity. This paper offers an overview of the literature of published research on coordination between biometals and anti - inflammatory drugs of the acid type. The metals that the subject of focus in this review are d - met als with M(II) ions, namely, copper (Cu), zinc (Zn), cobalt (Co) and manganese (Mn).Those containing molecules with carboxyl functional groups can build complexes with coordinated number of metals of 4 and 6, of various stoichiometric structures, simple or complex, and also behave as monodentate, bidentate or bridge ligands in polynuclear complexes.